Anke Penno Selected Research

Hereditary Sensory and Autonomic Neuropathies (HSAN)

1/2021	1-Deoxysphingolipids cause autophagosome and lysosome accumulation and trigger NLRP3 inflammasome activation.
1/2017	Localization of 1-deoxysphingolipids to mitochondria induces mitochondrial dysfunction.
12/2011	Oral L-serine supplementation reduces production of neurotoxic deoxysphingolipids in mice and humans with hereditary sensory autonomic neuropathy type 1.
6/2011	Characterization of two mutations in the SPTLC1 subunit of serine palmitoyltransferase associated with hereditary sensory and autonomic neuropathy type I.
10/2010	Mutations in the SPTLC2 subunit of serine palmitoyltransferase cause hereditary sensory and autonomic neuropathy type I.
4/2010	Hereditary sensory neuropathy type 1 is caused by the accumulation of two neurotoxic sphingolipids.
11/2009	Overexpression of the wild-type SPT1 subunit lowers desoxysphingolipid levels and rescues the phenotype of HSAN1.
4/2009	A systematic comparison of all mutations in hereditary sensory neuropathy type I (HSAN I) reveals that the G387A mutation is not disease associated.

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Anke Penno Research Topics

Disease

8	Hereditary Sensory and Autonomic Neuropathies (HSAN) 01/2021 - 04/2009
2	Type 2 Diabetes Mellitus (MODY) 01/2021 - 01/2017
1	Sandhoff Disease (Sandhoff's Disease) 01/2020
1	Male Infertility (Male Sterility) 01/2017
1	Gaucher Disease (Gaucher's Disease) 01/2017
1	Starvation 03/2013
1	Peripheral Nervous System Diseases (PNS Diseases) 12/2011
1	Neurodegenerative Diseases (Neurodegenerative Disease) 04/2009

Drug/Important Bio-Agent (IBA)

5	Serine C-PalmitoyltransferaseIBA 01/2021 - 04/2009
5	SphingolipidsIBA 01/2021 - 04/2010
3	EnzymesIBA 01/2020 - 10/2010
2	LipidsIBA 01/2017 - 03/2013
2	Serine (L-Serine)FDA Link 12/2011 - 04/2009
1	NLR ProteinsIBA 01/2021
1	Alkynes (Acetylenes)IBA 01/2021
1	Prolyl Hydroxylases (Prolyl Hydroxylase)IBA 01/2021
1	dihydroceramide desaturaseIBA 01/2021
1	4,4- difluoro- 4- bora- 3a,4a- diaza- s- indacene (BODIPY)IBA 01/2021
1	safingol (sphinganine)IBA 01/2021
1	fumonisin B1IBA 01/2021
1	Proteins (Proteins, Gene)FDA Link 01/2021
1	PTEN-induced putative kinaseIBA 01/2021
1	LipopolysaccharidesIBA 01/2021
1	Hexosaminidases (Hexosaminidase)IBA 01/2020
1	GangliosidesIBA 01/2020
1	GlucosidasesIBA 01/2017
1	SphingosineIBA 01/2017
1	antineoplaston A10 (A 10)IBA 12/2011
1	spisulosineIBA 10/2010
1	CeramidesIBA 04/2009
1	Palmitoyl Coenzyme A (Palmitoyl CoA)IBA 04/2009